Signaling molecules are necessary for the
coordination of cellular responses by serving as ligands and binding to
cell receptors.
Key Points
Signaling molecules can range from small proteins to small ions and can be hydrophobic, water-soluble, or even a gas.
Hydrophobic signaling molecules (ligands) can diffuse through the plasma membrane and bind to internal receptors.
Water-soluble ligands are unable to pass freely through the plasma
membrane due to their polarity and must bind to an extracellular domain
of a cell-surface receptor.
Other types of ligands can include gases, such as nitric oxide, which
can freely diffuse through the plasma membrane and bind to internal
receptors.
Terms
hydrophobic
lacking an affinity for water; unable to absorb, or be wetted by water
ligand
an ion, molecule, or functional group that binds to another chemical entity to form a larger complex.
Signaling Molecules
Produced by signaling cells and the subsequent binding to receptors in target cells, ligands act as chemical signals that travel to the target cells to coordinate responses.
The types of molecules that serve as ligands are incredibly varied and range from small proteins to small ions like calcium (Ca2+).
Small Hydrophobic Ligands
Small hydrophobic ligands can directly diffuse through the plasma
membrane and interact with internal receptors.
Important members of this class of ligands are the steroid hormones.
Steroids are lipids that have a hydrocarbon skeleton with four fused
rings; different steroids have different functional groups attached to
the carbon skeleton.
Steroid hormones include the female sex hormone, estradiol, which is a
type of estrogen; the male sex hormone, testosterone; and cholesterol,
which is an important structural component of biological membranes and a
precursor of steriod hormones .
Other hydrophobic hormones include thyroid hormones and vitamin D. In
order to be soluble in blood, hydrophobic ligands must bind to carrier proteins while they are being transported through the bloodstream.
Steroid Hormones
Water-Soluble Ligands
Water-soluble ligands are polar and, therefore, cannot pass through the
plasma membrane unaided; sometimes, they are too large to pass through
the membrane at all. Instead, most water-soluble ligands bind to the extracellular domain of cell-surface receptors.
Cell-surface receptors include: ion-channel, G-protein, and enzyme-linked protein receptors.
The binding of these ligands to these receptors results in a series of cellular changes.
These water soluble ligands are quite diverse and include small molecules, peptides, and proteins.
Other Ligands
Nitric oxide (NO) is a gas that also acts as a ligand.
It is able to diffuse directly across the plasma membrane; one of its
roles is to interact with receptors in smooth muscle and induce
relaxation of the tissue.
NO has a very short half-life; therefore, it only functions over short
distances.
Nitroglycerin, a treatment for heart disease, acts by triggering the
release of NO, which causes blood vessels to dilate (expand), thus
restoring blood flow to the heart.
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